A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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Halfway through his job, Cees Dekker reinvented himself. Following yrs of hardcore physics, he shifted his target to ‘nanobiology’ within the switch from the millennium. A expression he coined himself, as a subject of actuality.
Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular types with recombination purpose.
Around the similar time, the group of Paul McEuen, who was then based mostly in the College of California, Berkeley, showed very similar final results on ropes of bundled nanotubes. According to the wrapping angle, nanotubes can come in metallic or semiconducting variants, a prediction that we and Charles Lieber’s team at Harvard University independently verified making use of scanning tunnelling spectroscopy experiments.
2007, initial true-time detection of strand Trade in homologous recombination by RecA; discovery of a lower persistence duration of ends of microtubules; and solved the system of biosensing with carbon nanotubes
2015, discovery that condensin is really a really versatile protein structure; and first detection of DNA knots working with nanopores
Microbiology has only been around to get a century, considering that we began to analyze micro-organisms extra seriously. I thought nanobiology was an suitable phrase, since all molecular biological pertinent interactions take place on the nanoscale: a protein is several nanometres in measurement, DNA is 2 nm thick.’
‘At first we looked at Organic techniques by using a Bodily watch and acted on The premise with the applications we realized. It took a few years ahead of we started Operating additional on the massive biological problems. I then started to simply call it nanobiology, a term that did not exist at time.
Movement-driven rotary motors for instance windmills and h2o wheels drive practical processes in human Culture. While examples of these types of rotary motors also attribute prominently in mobile biology, their artificial design within the nanoscale has remained difficult. Right here we exhibit flow-pushed rotary motion of a self-structured DNA nanostructure that is definitely docked onto a nanopore in a thin good-point out membrane. An elastic DNA bundle self-assembles into a chiral conformation on phoretic docking on to the reliable-condition nanopore, and subsequently shows a sustained unidirectional rotary motion of up to 20 rev s−1.
2003, demonstrated the very first biosensors made from a carbon nanotube; settled ceesdekker.net the composition and mechanism of DNA repair proteins; and discovery of a different approach for fabricating good-condition nanopores for DNA translocation
It had been for the duration of this era that Dekker performed investigate on magnetic spin systems and on noise in superconductors and semiconductors.
An integrated microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
1999, initial measurement with the wavefunction of single molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for just a new Luttinger description of interacting electrons in nanotubes
2005, discovery on the system of DNA uncoiling by topoisomerase enzymes; discovery of extended-vary conformational adjustments in Mre11/DNA maintenance complexes; and very first drive measurements on a DNA molecule in a very nanopore
‘I'm pushed by ponder and concerns. On a fabric level I find answers in physics, but I encounter my deepest joy with God. That faith also drives my science and how I cope with folks.